2006•Shiyong yaowu yu linchuangRequires access
Therapeutic effects of midazolam on continuous status epileptics
Zhang Chun-li
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Abstract
Objective To observe the therapeutic effects of midazolam on continuous status epileptics(SE) by continuously given as a drip infusion,and to investigate the safe dosage and adverse reaction of it.Methods Forty-five children with SE were divided into two groups:in control group(24 cases),midazolam was continuously given as a drip infusion;in treatment group(21 cases),routine first-line anti-epileptic drugs(AEDs) was used,then comparing the therapeutic effects,and the safe dosages and side effects of midazolam were checked.Results There was significant difference in therapeutic effect of two groups(P0.05).The safe dosage of midazolam was less than 8 μg/(kg·min),and no serious side effect was observed.Respiratory depression was found in 3 cases when its dosage was more than 10 μg/(kg·min).Conclusion The effect of midazolam on SE by continuously iv is better than the routine first-line AEDs.Respiratory depression must be cared when midazolam's dosage was more than 10μg/(kg·min).