2006•Journal of Instrumental AnalysisRequires access

Determination of Vitamin B_4 with Luminol-H_2O_2 Chemiluminescence System

Lihua Shen, Xiaoxia Li

Abstract

A novel sensitive flow injection chemiluminescence(FI-CL) method for the determination of Vitamin B_4(VB_4) in pharmaceutical preparation is presented.It is based on the strong enhancement of VB_4 on the CL between Luminol and H_2O_2 in alkaline condition.Various factors affecting the CL emission intensity of the system have been studied.The enhancement of CL emission intensity is linear with the concentration of VB_4 in the range of 1.0×10~(-5)-1.0×10~(-2) g/L.The limit of detection is(3×)10~(-6) g/L(3σ).The relative standard deviation is 1.4% for 2.0×10~(-3) g/L VB_4 solution in eleven replicate measurements.It has been successfully applied to the determination of VB_4 in pharmaceutical preparation of tablets.

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Key concepts: Chemiluminescence, Chemistry, Luminol, Detection limit, Relative standard deviation, Chromatography, Linear range, Analytical Chemistry (journal)