Regulatory role of carbohydrate response element binding protein on hepatic glycolysis and lipogenesis

The liver is the major site of carbohydrate metabolism and lipogenesis.Carbohydrate response element binding protein(ChREBP) is a major transcription factor mediating hepatic glycolysis and lipogenesis.The heterodimer formed by ChREBP and Mlx can regulates hepatic expression of glucose-responsive genes required for glucose utilization and de novo lipogenesis.Specific inhibition of liver ChREBP in ob/ob mice can improve hepatic steatosis and insulin resistance.Understanding the roles of ChREBP in hepatic glycolysis and lipogenesis can further explain glucose-induced lipogenesis and may cast new lights on the treatment of metabolic diseases including hepatic steatosis.In this paper we introduce the molecular structure,biological function,and regulatory mechanisms of ChREBP,as well as its relationship with metabolic diseases.