Clinical significance of MGMT expression in human glioma

Objective:To explore the relationship between glioma and the activity of MGMT.Methods:Total of 53 samples of glioma were divided into 4 groups,tected by immunohistochemistry.Results:The positive staining of gliomas was localized in the cytoplasm of tumor cells.The mean positive expression of MGMT was 26 in 53(49.1%);The difference of MGMT expression among gradeⅠ~Ⅳwas not significant(P=0.335);there was no significant difference in the MGMT positive expression of different age groups(P=0.457);The positive rate of MGMT expression between male and female was not significant different(P=0.519).Conclusion:The positive expression of MGMT in human brain glioma does not correlate with the age or gender of patients and the tumor grade;The use of alkylating agents chemotherapy is unscientific solely on the basis of the tumor grade;the expression level of MGMT might be useful in judging the resistance of alkylating agents in chemotherapy of glioma.