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IRRADIATION-INDUCED APOPTOSIS OF BONE MARROW HEMATOPOIETIC CELLS IN MICE: A STUDY OF TIME- AND DOSE-EFFECT RELATIONSHIPS IN VIVO

Zou Zhong

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Abstract

By means of flow cytometry and DNA electrophoresis, in this experiment we investigate that in what extent apoptosis was taken by the radiation injured-bone marrow hematopoietic cells(BMHCs)of 4-10Gy 7-ray irradiated-mice. The significant time-and dose-effect relationships of radiation-induced apoptosis of BMHCs was found. The peakvalues of apoptosis induced by 6Gy and 8Gy radiation were about 30%, and by 4Gy and 10Gy radiation 20%. The time needed to reach the peak was shortened correspondingly when dose inereased, shown as 12,8.4 and 4h for 4,6,8 and 10Gy irradiation respectively. The results demonstrate that apoptosis is an important cell death pathway taken by the radiation-injured BMHCs in vivo, so further investigation on the regulation of apoptosis would highlight the mechanism of radiation-induced hematopoiesis dysfunction.

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What this paper is about

By means of flow cytometry and DNA electrophoresis, in this experiment we investigate that in what extent apoptosis was taken by the radiation injured-bone marrow hematopoietic cells(BMHCs)of 4-10Gy 7-ray irradiated-mice. The significant time-and dose-effect relationships of radiation-induced apoptosis of BMHCs was found. The peakvalues of apoptosis induced by 6Gy and 8Gy radiation were about 30%, and by 4Gy and 10Gy radiation 20%. The time needed to reach the peak was shortened correspondingly when dose inereased, shown as 12,8.4 and 4h for 4,6,8 and 10Gy irradiation respectively. The results demonstrate that apoptosis is an important cell death pathway taken by the radiation-injured BMHCs in vivo, so further investigation on the regulation of apoptosis would highlight the mechanism of radiation-induced hematopoiesis dysfunction.

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Available abstract

By means of flow cytometry and DNA electrophoresis, in this experiment we investigate that in what extent apoptosis was taken by the radiation injured-bone marrow hematopoietic cells(BMHCs)of 4-10Gy 7-ray irradiated-mice. The significant time-and dose-effect relationships of radiation-induced apoptosis of BMHCs was found. The peakvalues of apoptosis induced by 6Gy and 8Gy radiation were about 30%, and by 4Gy and 10Gy radiation 20%. The time needed to reach the peak was shortened correspondingly when dose inereased, shown as 12,8.4 and 4h for 4,6,8 and 10Gy irradiation respectively. The results demonstrate that apoptosis is an important cell death pathway taken by the radiation-injured BMHCs in vivo, so further investigation on the regulation of apoptosis would highlight the mechanism of radiation-induced hematopoiesis dysfunction.

Key concepts: Apoptosis, In vivo, Haematopoiesis, Bone marrow, Biology, Flow cytometry, Irradiation, Cell biology

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IRRADIATION-INDUCED APOPTOSIS OF BONE MARROW HEMATOPOIETIC CELLS IN MICE: A STUDY OF TIME- AND DOSE-EFFECT RELATIONSHIPS IN VIVO — Research Paper | ScholarLens