Application of Etomidate or Propofol Target Controlled Infusion in the Elderly Hypertensive Patients

Objective To compare with the effects of etomidate or propofol target controlled infusion(TCI)on hemodynamics and recovery in the elderly hypertensive patients.Methods Sixty elderly hypertensive patients with underwent laparoscopic operation were randomized into etomidate group(Group E)and propofol group(Group P),each group was 30 cases.Patients in Group E were induced and maintained with TCI etomidate and remifentanil,patients in Group P were induced and maintained with TCI propofol and remifentanil.The systolic blood pressure(SBP),diastolic blood pressure(DBP)、heart rate(HR)、recovery time index and adverse reaction were recorded before anesthesia induction(T0),l min before tracheal intubation(T1),2 min after tracheal intubation(T2),3 min after insert laparoscope(T3),3 min after exploration(T4)and 3 min after tracheal extubation(T5)respectively.Results Compared with T0,SBP,DBP and HR decreased significantly in both groups at time T1(P0.05);but group E has a better hemodynamics than group P(P0.05);HR in group P decreased significantly at time T3(P0.01).There was no any significant difference in the side effect rate(P0.05).The recovery time in group E was longer than that of group P(P0.05).Conclusion Group E is easier to maintain stable hemodynamics than group P,but the recovery time may be prolonged in the elderly hypertensive patients.