Analysis of the causes and characteristic of amputation in diabetic patients with peripheral neuropathy

Objective To analyze the causes and characteristics of amputation in diabetic patients with peripheral neuropathy,in order to provide preliminary information to prevent the amputation.Methods 136 cases of diabetic patients with peripheral neuropathy treated with amputation were analyzed.Results The main reason for amputation of DPN patients with peripheral vascular disease(peripheral arterial disease,PAD) was foot osteomyelitis(36.2%),followed by mixed gangrene(25%),and dry gangrene(18.1%),which was significantly higher than that DPN group.Locations of amputation in these patients were mainly below the ankle joint(72.4%).The number of cases of amputation in patients with DPN alone accounted for only 14.7% of total number of cases,the amputation is mainly due to wet gangrene(65%),the ratio was significantly higher than the DPN group merged with PAD,followed by Charcot joint disease(20%) and trauma(10%).Locations of amputation in these patients were mainly above the ankle joint(85%).Conclusion DPN increases risk of amputation in diabetic patients with PAD,and foot osteomyelitis,mixed and dry gangrene are the main reason for amputation.Wet gangrene is the main reason for amputation in patients with DPN alone.Amputation in DPN combined PAD patients is more common below the ankle joint while the amputation in patients with DPN alone above the ankle.