Observation on the Effect of Sub-anesthetic Doses of Ketamine and Fentanyl in Children's Regional Anesthesia

Objective: To study the clinical effect of sub-anesthetic doses of ketamine and fentanyl in children's regional anesthesia. Method: 50 children with minor surgeries in our hospital were randomly divided into experimental group and control group,with 25 cases in each group.The two groups were all preoperatively fasted and given atropine by intramuscular injection,the control group were given ketamine 5mg/kg by intramuscular injection,and then they were given 1/3 to 1/2 of first dose ketamine to maintain anesthesia,the experimental group were first given ketamine 5mg/kg by intramuscular injection,then they were given anesthesia induction with fentanyl 1-2μg/kg after vein open,and the subsequently 0.1% ketamine were given at 2-4mg.kg-1.h-1,5-10mL/h by micro pump,the dose was kept at 2-8mL/h. Result: The body movement time or eye opening time,operation leaving time and postoperative awaking time of experimental group were all significantly shorter than those of control group(P0.05),the AONO restlessness scale of experimental group was(2±1.0)points,the control group was(3±1.4)points,,there were significantly differences between the two groups(P0.05). Conclusion: The clinical effect of sub-anesthetic doses of ketamine and fentanyl in children's regional anesthesia is better than that of only ketamine anesthesia,the waking time of patients is shorter,physiological disturbance and adverse reaction are less,and it is suitable for small and middle and small operation of children.