2002•Chinese Journal of Spine and Spinal CordRequires access
Effect of exogenous GDNF on motor function recovery following spinal cord injury in rats
Tiesheng Hou
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Abstract
Objective:The aim of the study is to investigate the effect of exogenous GDNF on spinal cord locomotor function recovery after spinal cord injury(SCI)in adult rats. Method:The SCI model of acute posterior spinal cord compression injury was established in rats according to the method of Nystrom. The recombinant rat GDNF or NGF was injected into the injured region upon intrathecal tubutization in first week after SCI, the control group instead of normal saline(NS). The aere of remaining injured spinal cord tissue was calculated by HE staining. The locomotion function of hindlimbs of rats was evaluated using inclined plane test and BBB locomotor scale. Result: The locomotion functional scales of rats in GDNF group were higher than that in NS group and NGF group within 4 to 14 days after SCI(P0.05). Four weeks after SCI, the area of remaining injured spinal cord tissue in GDNF group was larger than that in NS group and NGF group (P 0.01). Conclusion: These results indicate that exogenous GDNF may enhance locomotion functional restoration of hindlimbs as well as decreased tissue death and atrophy of lesion cord.