Adrenogenital syndrome (report of 12 cases)

bjective To study the morbidity,etiology,differential diagnosis and treatment of adrenogenital syndrome. Methods 12 cases of adrenogenital syndrome,3 male and 9 female,have been admitted and treated from 1981 to 1996.There were 6 cases of adrenocortical adrenal hyperplasia (CAH) and 6 cases of adrenocortical carcinoma.In addition,a total of 264 cases reported in China were reviewed. Results In 6 cases of CAH,4 were masculization and 2 virilize prococious puberty.Increased 17ks,positive dexmathasone inhibition test and bilateral adrenal hyperplasia on imaging procedure were characteristic.In the 6 cases of adrencortical carcinoma,masculization was noted in all with negative dexamathasone inhibition test.On image examination,a spaceoccupying mass was found in the adrenal gland in all the 6 cases. Conclusions The morbidity of adrenogenital syndrome seems to be increasing because of better diagnostic procedures and the constituent ratio of CAH and adrenocortical carcinoma is changing.17ks assay,dexamathasone inhibition test and image examination render great help to the differential diagnosis between CAH,adrenal adenoma and adrenocortical carcinoma.