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Alteration in peripheral blood CD_5~+B cells is associated with disease activity in Graves′ disease

YE Fe

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Abstract

Peripheral blood CD_5~+B cell was detected by flow cytometry in patients with Graves′ disease (GD) before and after treatment. As compared with normal controls, peripheral blood CD_5~+B cells in a group of 43 patients with GD showed a significant increase in number [(17.0+5.1)% vs (39.5+12.4)%, P0.01]. After treatment, peripheral blood CD_5~+B cells showed a significant decrease in patients with GD (P0.01). There were positive correlations between numbers of peripheral blood CD+5B cells and serum levels of FT4,FT3,TT4,TT3 in the patients with GD.

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What this paper is about

Peripheral blood CD_5~+B cell was detected by flow cytometry in patients with Graves′ disease (GD) before and after treatment. As compared with normal controls, peripheral blood CD_5~+B cells in a group of 43 patients with GD showed a significant increase in number [(17.0+5.1)% vs (39.5+12.4)%, P0.01]. After treatment, peripheral blood CD_5~+B cells showed a significant decrease in patients with GD (P0.01). There were positive correlations between numbers of peripheral blood CD+5B cells and serum levels of FT4,FT3,TT4,TT3 in the patients with GD.

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Available abstract

Peripheral blood CD_5~+B cell was detected by flow cytometry in patients with Graves′ disease (GD) before and after treatment. As compared with normal controls, peripheral blood CD_5~+B cells in a group of 43 patients with GD showed a significant increase in number [(17.0+5.1)% vs (39.5+12.4)%, P0.01]. After treatment, peripheral blood CD_5~+B cells showed a significant decrease in patients with GD (P0.01). There were positive correlations between numbers of peripheral blood CD+5B cells and serum levels of FT4,FT3,TT4,TT3 in the patients with GD.

Key concepts: Peripheral blood, Peripheral, Internal medicine, Flow cytometry, Endocrinology, Medicine, Graves' disease, Disease

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