Effect of bisoprolol combined with tiotropium in treatment of 40 cases with stable chronic obstructive pulmonary disease

Objective To investigate bisoprolol combined tiotropium bromide in the treatment of chronic obstructive pulmonary disease(COPD) and stable curative effect and safely of patients.Methods Patients with stable(JOPD(80 cases)were randomly divided into tiotropium group(control group) and bisoprolol with tiotropium group(observation group) with 40cases in each group.The control group on the basis of conventional therapy,given tiotropium bromide powder for inhalation,the observation group was treated with small dose of bisoprolol tablets,according to the conditions of patients adjust the dose,duration of treatment was 12 weeks;compared to the total efficiency,and the 2 groups before and after treatment,COPD assessment test(CAT) score and pulmonary function of acute exacerbation the situation.Results Observation group completed the trial in 34 cases,36 cases in the control group completed the trial.Alter treatment,the observation group and the control groups total effective rate was 80.56%(29/36) and 97.06%(33/34),the difference was statistically significant(P 0.05).Before treatment,the control group and the observation group FEV_1,FEV_1%,FEV_1/FVC,CAT scores were(1.58 ±0.57)1.,(41.73 ±5.74)%,(56.73 ±4.74)%,(23.9 ±4.8) points and(1.56 ±0.63) L,(42.26 ±5.13)%,(57.33 ±3.95)%,(24.2 ±4.3)points,no significant differences between the 2 groups(all P 0.05).After treatment,the observation group and the control group's FEV_1 FEV_1%,FEV,/ FVC,CAT scores were(1.89 ± 0.33) L,(49.23 ± 3.53)%,(59.83 ±5.53)%,(16.3 ±3.7) points and(2.02 ±0.31)L,(53.53 ±4.34)%,(63.46 ±6.17)%,(13.6 ±3.3) points,acute exacerbation were found in 11 patients(30.6%) and 4 patients(11.8%) respectively,compared with before treatment,the difference between the 2 groups were statistically significant(P 0.05);and the observation group were improved significantly compared with the control group,the difference was statistically significant(P 0.05).Conclusion Bisoprolol combined with tiotropium than the simple use of tiotropium bromide can improve the patients with stable COPD pulmonary function and quality of life;fewer acute exacerbation period of stability,and associated with adverse reactions did not significantly increase.