Evaluation of sufentanil for!sedation and analgesia during operation under local anesthesia

Objective To evaluate the efficacy and safety of intravenous sufentanil for sedation and analgesia during surgery under local anesthesia.Methods Sixty ASA class Ⅰ or Ⅱ patients(21 male,39 female)undergoing the elective plastic surgery and requiring sedation and analgesia were randomly divided into three groups with 20 patients each.Continuous infusion of fentanyl was used in group F,sufentanil infusion was given in group S and target controlled infusion of sufentanil in group TCI.Five minutes before local anesthesia,fentanyl was given at a loading dose of 1 μg/kg and followed by infusion of 1 μg·kg-1·h-1 in group F,sufentanil a loading dose of 0.1 μg/kg followed by infusion of 0.1 μg·kg-1·h-1 in group S,and sufentanil by target controlled infusion of 0.2-0.1 ng/ml in group TCI.Midazolam was used in three groups.Result There were no significant differences among three groups in awaking time,vital signs including BP,HR,SpO2,RR and side effects including nausea,emesis,nightmare,blurred vision.VAS of TCI group was significantly less than that of group F and S at T1 and T2(P0.01).The patients of RSS at grade IV were more in group TCI than those in group F at T1 and T2(P0.05).Midazolam requirement was significantly less in group TCI than that in group F and S at T1(P0.01).The total amount of opioid in group TCI was lower than that in group F(P0.05).Conclusion Sufentanil is effective and safe for sedation and analgesia,especially given by TCI.