Clinical efficacy studies of low-molecular-weight heparin in the treatment for sepsis

Objective To evaluate the efficacy of low molecular weight heparin in patients with sepsis . Methods A total of 24 patients with sepsis were randomly divided into LMWH treatment group and control group. Both groups were examined TAT,AT-Ⅲ,PC,PS,PLT,PT,APTT,Fbg,D-d,FDP and severity score. Results PC and PS in these two groups were increased after treatments,and those of LMWH treatment group were increased more significantly than those of control group; there was a significant difference between these two groups (P 0.001). TAT in these two groups fell after treatments,and that of LMWH treatment group fell more significantly than that of control group, but there was no statistic difference between these two groups (P 0.05). Severity score in these two groups was increased after 2 days′treatment; severity score in LMWH treatment group was increased more significantly than that of control; there was a significant difference between these two groups (P 0.05). Conclusion Low dosage of low molecular weight heparin treatment in patients with sepsis is effective on improving function of hemorrhagic-coagulation and the clinical condition without complications of bleeding.