Effect of fast track surgery on immune function after laparoscopic operation for elderly patients with colorectal cancer

Objective: To investigate the influence of fast track surgery( FTS) on the immune function after laparoscopic operation for elderly patients with colorectal cancer. Methods: Sixty-one patients older than 65 years with colorectal cancer were randomized to receive traditional protocol and laparoscopic surgery( group Ⅰ,n = 30),FTS and laparoscopic surgery( groupⅡ,n = 31). C reactive protein( CRP),interleukin-6( IL-6),CD4+,CD8+,CD4+/CD8+,IgA,IgM,IgG were tested 1 d before operation,3 and 7 d after operation. Results: On the postoperative 3rd and 7th day,CRP and IL-6 significantly increased as compared to preoperative data in two groups( P 0. 05),but the parameters in group Ⅰ were significantly higher than those in group Ⅱ( P 0. 05). On the postoperative3 rd day,IgA,IgM and IgG significantly decreased as compared with preoperative data in two groups( P 0. 05),and IgM in group Ⅰwas significantly lower than that in group Ⅱ( P = 0. 002). On the postoperative 7 th day,there were no significant differences in IgG,IgM and IgA between before and after operation. On the postoperative 3rd day,CD4+,CD8+and CD4+/CD8+significantly decreased as compared with preoperative data in two groups( P 0. 05),and the parameters in group Ⅰ were significantly lower than those in group Ⅱ( P = 0. 03,P = 0. 024,P = 0. 002). On the postoperative 7th day,there were no significant differences of CD4+,CD8+and CD4+/CD8+between before and after operation in group Ⅱ,but CD8+in group Ⅰ was still lower than preoperative parameter( P= 0. 008). Conclusions: FTS and laparoscopic operation have fewer influences on immune function of elderly patients with colorectal cancer,and are worth popularization.