The effects of anesthesia induction with sevoflurane on the onset of cis-atracurium

Objective To compare the induction quality of intravenous propofol and inhalational sevoflurane on the skelaxin onset time of cis—atracurium.Methods Sixty ASA Ⅰ or II patients,aged from 18 to 65,undergoing selective surgery with general anesthesia,were equally randomized into two groups,group P with intravenous propofol,group S with inhalational sevoflurane.Group P:intravenous induction with midazolam 0.05 mg/kg,fentanyl 2 μg/kg,propofol 1 mg/kg.Group S:inhalation of 8% sevoflurane in vital capacity respiration.0.15 mg/kg cis-atracurium was infused after loss of consciousness in both groups.Time for loss of eyelash reflex,hemodynamic changes,onset time of cis-atracurium and conditions of tracheal intubation were recorded.Results The time to loss of eyelash reflex in group S is significantly shorter than that in group P(P0.05).The onset time of cis-atracurium in group S is significantly shorter than that in group P(P0.01).Tracheal intubation causes less stress response in group S than in group P(P0.05).Conclusion Sevoflurane induction can greatly shorten the onset time of cis-atracurium with stable hemodynamic state.