Clinical Analysis of Atorvastatin Statin combined with Ezetimibe for Coronary Heart Disease with Hypercholesterolemia

Objective:To investigate the clinical efficacy and safety of atorvastatin statin combined with ezetimibe for the treatment of coronary heart disease with hypercholesterolemia. Method:72 cases of patients with coronary heart disease were randomly divided into two groups. 36 cases in the control group were treated with atorvastatin statins,while the other 36 cases in the observation group were treated with ezetimibe on the basis of t atorvastatin statins. Every two weeks was a course of treatment,and the comprehensive evaluation of efficacy and safety were estimated and compared based on the incidence of adverse reactions,and the liver and kidney function indicators after three courses. Result:High cholesterol and inflammation:After treatment,the serum TC,LDL-C and hs-CRP levels of the observation group were significantly lower than the control group( P 0.05),while there was no significant difference in the two groups of patients with HDL-C levels( P 0.05);liver and kidney damage and adverse reactions:After treatment,the ALT UN level of the observation group were significantly lower than the control group( P 0.05),while there was no significant difference in the two groups of patients with CRE levels( P 0.05).The incidence of adverse reactions of the observation group was significantly less than the control group( P 0.05). Conclusion:It is an efficient method with little clinical side effects for atorvastatin statin combined with ezetimibe to treat coronary heart disease with hypercholesterolemia which is worth to be promoted.