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2009•Journal of Clinical HematologyRequires access

The effect of IC163 on inhibiting the growth of K562 and inducing apoptosis

Guangsen Zhang

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Abstract

Objective:To determine the effects of growth inhibition and apoptosis induction of IC163 on K562 leukemia cells.Method:K562 cells were treated with different concentrations of IC163.The cell viability were analyzed with MTT assay,the percentage of apoptosis cells was analyzed by Hochest33258 staining and Annexin V/PI via flow cytometric.Result:IC163 can significantly inhibit the proliferation of K562 cells in a concentration-dependent manner,and the IC50 was 18.1 μmol/L;IC163 can induce the apoptosis of K562 cells with an up-regulated Caspase-3 expression and cleavage actation.Conclusion:IC163 could efficiently inhibit the proliferation of K562 cells and induce the apoptosis of K562 cells.So IC163 maybe a potencial anti-leukemia drug.

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What this paper is about

Objective:To determine the effects of growth inhibition and apoptosis induction of IC163 on K562 leukemia cells.Method:K562 cells were treated with different concentrations of IC163.The cell viability were analyzed with MTT assay,the percentage of apoptosis cells was analyzed by Hochest33258 staining and Annexin V/PI via flow cytometric.Result:IC163 can significantly inhibit the proliferation of K562 cells in a concentration-dependent manner,and the IC50 was 18.1 μmol/L;IC163 can induce the apoptosis of K562 cells with an up-regulated Caspase-3 expression and cleavage actation.Conclusion:IC163 could efficiently inhibit the proliferation of K562 cells and induce the apoptosis of K562 cells.So IC163 maybe a potencial anti-leukemia drug.

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Available abstract

Objective:To determine the effects of growth inhibition and apoptosis induction of IC163 on K562 leukemia cells.Method:K562 cells were treated with different concentrations of IC163.The cell viability were analyzed with MTT assay,the percentage of apoptosis cells was analyzed by Hochest33258 staining and Annexin V/PI via flow cytometric.Result:IC163 can significantly inhibit the proliferation of K562 cells in a concentration-dependent manner,and the IC50 was 18.1 μmol/L;IC163 can induce the apoptosis of K562 cells with an up-regulated Caspase-3 expression and cleavage actation.Conclusion:IC163 could efficiently inhibit the proliferation of K562 cells and induce the apoptosis of K562 cells.So IC163 maybe a potencial anti-leukemia drug.

Key concepts: K562 cells, Apoptosis, Annexin, Flow cytometry, Leukemia, Chemistry, MTT assay, Cell growth

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