Effect of midazolam, fentanyl and propofol coinduction on hypnotic and sedation in gengerl anesthesia

AIM: To investigate hypnotic and sedation interaction between midazolam, fentanyl and propofol in coinduction in general anesthesia. METHODS: Sixty patients, ASA class Ⅰ or Ⅱ, scheduled for elective celoscope operation were evenly distributed to 6 different compound dose groups according to weighted modification method. Anesthesia was induced with midazolam which was administered over 15 s,and fentanyl which was administered over 15 s, and propofol which was administered over 30 s, then rocuronium 0.6 mg·kg~(-1) was administered to facilitate tracheal intubation. BIS, MAP, HR were recorded at following times: before induction, 1 and 2 min after induction, just at intubation, 1 and 3 and 5 and 7 min after intubation. RESULTS: The important degree of every drug was as follow: propofol fentanyl midazolam. The optimal combinations was midazolam 0.02 mg·kg~(-1), fentanyl 0.0025 mg·kg~(-1) and propofol 0.8 mg·kg~(-1). The optimal ratio was 1.0:0.125: 40. The nature of interaction was additive. CONCLUSION: The midazolam, fentanyl and propofol combination possess addtitive interaction in sedation and hypnosis. The optimal combinations was midazolam 0.02 mg·kg~(-1), fentanyl 0.0025 mg·kg~(-1) and propofol 0.8 mg·kg~(-1).