Clinical Effect of Paroxetine and Propranolol in the Treatment of Generalized Anxiety

Objective To observe the clinical effect and adverse effect of paroxetine and propranolol in the treatment of generalized anxiety.Methods Totally 205 patients were randomly divided as trial group(paroxetine plus propranolol,n=105)and control group(paroxetine,n=100),the treatment for each was six weeks.Hamilton Anxiety Rating Scale(HAMA)and Clinical Global Impression(CGI)were taken to evaluate clinical effect,and the safety was assessed by Treatment Emergent Symptoms Scale(TESS).Results The total effective rates of the trial group and the control group were 87.8% and 75.5% respectively,with a significant difference between two groups(P0.05);and the effect-starting time in the trial group was earlier than that in the control group.The reducing rates in HAMA and HAMD in the trial group were significantly higher than those in the control group at 2,4,6weeks(P0.01).The adverse effects such as headache,tachycardia,and tremor in the trial group were less and lighter than those in the control group.Conclusion Paroxetine plus propranolol has good efficacy and safety in treating generalized anxiety,which is better than paroxetine used only.