Clinical significance of detecting large surface protein of hepatitis B virus in patients

Objective:To study the clinical significance of detecting the hepatitis B virus large surface protein and its association with HBeAg and HBV-DNA.Methods:Sera of 273 HBV patients were collected.HBV-LP and HBVM was measured by enzyme linked immunosorbent assay(ELISA),HBV-DNA level was quantitatively detected by using real-time polymerase chain reaction.Results:Among the 273 cases,the positive rate of HBV-LP was significantly different in different HBV-DNA copy numbers(P0.05).In HBeAg-positive patients,there was no significant difference between the positive rate of HBV-DNA and HBV-LP(P0.05).The positive rate of HBV-LP was significant higher than the positive rate of HBV-DNA in HBeAg negative samples(P0.05).Conclusion:HBV-LP is a new serological marker which can reflect the viral replication,disease progression,curative effect and prognosis of HBV patients.