MR Quantitative Susceptibility: Comparision of Spontaneous Intracerebral Hemorrhage and Cerebral Microbleeds in Lacunar Infarction

Objective To analyze the difference of quantitative susceptibility mapping(QSM) between spontaneous intracerebral hemorrhage(ICH) and cerebral microbleeds(CMBs) in lacunar infarction,and to evaluate the feasibility of magnetic susceptibility in the forecast CMBs risk.Methods 83 patients with ICH(34 cases) and lacunar infarction(49 cases) were collected in the study.The patients underwent MR multi echo QSM in 3T MR scaner.The MR quantitative susceptibility,diameter and Signal characteristics of CMBs were analyzed in all cases.T test comparison analysis was used to find the difference of diameter and quantitative susceptibility between ICH group and lacunar infarction group.The spearman correlation was used to determine the correlation of quantitative susceptibility and its diameter.Results The MR quantitative susceptibility of CMBs in ICH group and lacunar infarction group were(11.78±7.18)ppm·mm3 and(6.16±2.95) ppm·mm3,which had significant difference(t=3.59,P0.01) between the two groups.The diameter of CMBs were(4.03±1.16)mm and(3.05±0.9)mm respectively,and there was significant difference(t=3.39,P0.01) between the two groups.There was no significant correlation(r = 0.64,P 0.01) between the quantitative susceptibility and diameter.Conclusion MR quantitative susceptibility can directly explicate the evolution law of CMBs.MR quantitative susceptibility may be a reliable indicator in the forecast of CMBs risk.