Comparison of propofol with midazolam propofol for sedation in fiberoptic bronchoscopy

OBJECTIVE To compare the sedation effects and patient satisfaction of propofol with midazolam in fiberoptic bronchoscopy.METHODS Sixty-eight patients undergoing fiberoptic bronchoscopy were randomly divided into propofol group(P group)and midazolam group(M group).After topical lidocaine anesthesia,the patients in group P were administered intravenous injection of propofol by the initial dose of 1.5mg·kg-1,slowly with the speed of 40～60s,then 5 ～ 10mg/(kg·h) infusion;The patients in Group M were given intravenous midazolam of 2mg bolus,and after 2min were given increments of 0.5mg,interval 2min.Maintenance of medication were adjusted according to sedation grade of the patients so that the sedation state was between sleep with eyes closed and wake-up under loud command.Sedation induction time,consciousness recovery time,the incidence of hypoxemia,cough degree,the requirement dose of local anesthesia drug,as well as the patient satisfaction.RESULTS The sedation induction time were 48±16s(P group),210±49 s(M group),the awareness recovery time were 4.9±1.8min(P group),15.1±5.7min(M group),the sedation induction time and the awareness recovery time in group P were significantly shorter than group M,the difference was significant(P0.05).The diffences of the incidence of hypoxemia,cough degree,requirement dose of local anesthesia drug,as well as patients satisfaction between two groups were no significant(P0.05).CONCLUSION Propofol and midazolam are safe for fiberoptic bronchoscopy sedation,but the sedation induction time was short time with propofol,the patients with propofol restored consciousness rapidly.