Relationship between serum prostate specific antigen and chronic prostatitis

Objective: To study the relationship between serum prostate specific antigen (PSA) and chronic prostatitis in patients with benign prostatic hyperplasia (BPH). Methods: There were 128 outpatients who presented with BPH and serum PSA greater than 4.0 ng/ml and were subsequently diagnosed with chronic prostatitis. All patients were treated with a 6-week course of anti-inflammation agent (celecoxib). Patients were divided into three groups according to the levels of serum PSA and the results of prostatic biopsy. Results: There was statistically differences after treatment in the group with serum PSA less than 4.0 ng/ml and not the other two. The positive rate of diagnosis in prostate cancer after treatment was great higher than that before treatment. Conclusions: Patients who are presented with BPH and serum PSA greater than 4.0 ng/ml and are subsequently diagnosed with chronic prostatitis, can be treated with anti-inflammation agent to elevate the specific rate of diagnosis in prostate cancer. Biopsies are not necessary for the patients who are presented with serum PSA less than 4.0 ng/ml.