The change of serum angiotensin1 converting enzyme in acute pulmonary embolism rats

Objective To explore the change of serum angiotensin1 converting enzyme in acute pulmonary embolism(PE).Methods Twenty-four SD rats were randomized into three groups:control group(n=8),embolism for 24 h group(n=8) and embolism for 1 week group(n=8).Embolism rats were injected with medical gelfoam microspheres via jugular vein to establish the PE model and the control rats were injected with saline.The rats were sacrificed after 1 week for control group and 24 h and 1 week for embolism groups.Arterial blood was collected at the time of sacrifice for blood gas analysis and serum angiotensin-converting enzyme determination.Lung tissue sections were made and stained with HE to observe the embolism of pulmonary arteries.Results The mean pulmonary pressures of control group,embolism for 24 h group and embolism for 1 week group were(14.2±4.1) mm Hg,(26.1±7.5) mm Hg and(26.1±6.8) mm Hg respectively.The arterial O2 partial pressures were(94.1±8.8) mm Hg,(80.5±5.8) mm Hg and(80.4±13.8) mm Hg respectively(P0.05).The levels of serum angiotensin1 converting enzyme were(30.5±7.2) U/L,(53.5±15.9) U/L,(45.8±17.4) U/L respectively.After 24 h of embolism,pulmonary arteries were shown to be embolized by gelfoam,which was resolved partly after 1 week.Conclusions The level of serum angiotensin1 converting enzyme increased significantly in acute pulmonary embolism,the extent of which may be related to the extent of obstruction of the pulmonary vascular bed.