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Research Progresses of NRG/ErbB Signaling Pathways in Nervous System

Tian Yu-k

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Abstract

Neuregulin(NRG)is a signaling transduction protein among cells,the functional receptors of which are ErbB tyrosine kinases receptors,members of the EGF receptor superfamily,which includes:ErbB1,ErbB2/Her2/neu,ErbB3/HER3,and ErbB4/HER4.NRG via inducing ErbB dimerization activates the ErbB kinase domain,resulting in C-ferminal end auto-and trans-phosphorylation of the intracellular domains,playing its biological role through invoking downstream signaling pathway transduction.

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What this paper is about

Neuregulin(NRG)is a signaling transduction protein among cells,the functional receptors of which are ErbB tyrosine kinases receptors,members of the EGF receptor superfamily,which includes:ErbB1,ErbB2/Her2/neu,ErbB3/HER3,and ErbB4/HER4.NRG via inducing ErbB dimerization activates the ErbB kinase domain,resulting in C-ferminal end auto-and trans-phosphorylation of the intracellular domains,playing its biological role through invoking downstream signaling pathway transduction.

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Available abstract

Neuregulin(NRG)is a signaling transduction protein among cells,the functional receptors of which are ErbB tyrosine kinases receptors,members of the EGF receptor superfamily,which includes:ErbB1,ErbB2/Her2/neu,ErbB3/HER3,and ErbB4/HER4.NRG via inducing ErbB dimerization activates the ErbB kinase domain,resulting in C-ferminal end auto-and trans-phosphorylation of the intracellular domains,playing its biological role through invoking downstream signaling pathway transduction.

Key concepts: ErbB, Neuregulin, Signal transduction, Receptor tyrosine kinase, ERBB3, ERBB4, Neuregulin 1, Cell biology

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