Evaluation of renal function in urinary obstruction by ~(99)Tc~m-DTPA imaging calculated GFR with renal cortecal ROI

Objective To evaluate renal function in urinary obstruction by 99Tcm-DTPA renal dynamic imaging calculated glomerular filtration rate ( GFR ). Methods The renal function of 30 cases with upper urinary-tract obstruction were evaluated by GFR calculated with 99Tcm-DTPA renal dynamic imaging u-sing two different region of interest (ROI) : the whole renal ROI and the renal eortecal ROI, and were correlated with urinary albumin (Alb). Results With the increasing severity of the hydronephrosis, the urinary Alb increased in both groups, while the two different ROI calculated GFR were decreased. Besides, the renal fortecal ROI method was much more negatively correlated with the urinary Alb level. Conclusion The GFR calculated by 99Tcm-DTPA renal dynamic imaging is a reliable parameter for detection of the damage of glomerular filtration function in obstructive urinary diseases and the GFR calculated by renal eortecal ROI may provide more sensitively and accurately.