2007•Unpublished venueRequires access
Synthesis of 4-Phenyl-6-Methyl-5-Ethoxycarbonyl-3,4-Dihydropyrimidin-2(H)-One Catalyzed with H_3PW_6Mo_6O_(40)
Tong Wen-long
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Abstract
4-Phenyl-6-methyl-5-ethoxycarbonyl-3,4-dihydropyrimidin-2(H)-one was synthesized from benzaldehyde, ethyl acetoacetate, and urea with H3PW6Mo6O40 as catalyst and anhydrous ethanol as solvent. The effects of reaction conditions on the yield of the product were investigated and the optimum conditions were determined as follows:n(benzaldehyde)∶n(ethyl acetoacetate)∶n(urea 37.5 mmol)=1.0∶1.2∶1.5, the quantity of catalyst was 1.5% quantity of the feed stock, reaction temperature 60℃, and reaction time 1.0 h. The yield of the product was up to 44.6%.