Dynamic Changes and Its Significance of Plasma Nitric Oxide Level in Rabbits during Hemorrhagic Shock Resuscitation

The paper deals with the changes and its significance of nitric oxide synthase (NOS)activity and nitric oxide products ( NO1- /NO3-) content in plasma during hemorrhagic shock resuscitation as well as the protective effect of taurine on it/rhe model of hemorrhagic shock resuscitation was used. Sixteen rabbits were divided randomly into 2 groups( n = 8): shock group, taurine group. The activities of NOS, the contents of nitric oxide products(NO2-/NO3- ) in plasma and mean artery pressure (MAP) were observed before shock and shock 1 .5 hours, after resuscitation 1 hour, 2 hours and 3 hours. Result shows: During resuscitation, the activities of NOS and the contents of NO2-/NO3- in plasma of shock group were significantly higher than that of before shock and shock 1 .5 hours( P 0.01) ,the MAP of shock group were significantly lower than that of before shock ( P 0.01) .Taurine(40 mg·kg-1 ,iv) could attenuate all the changes mentioned above at total time points of reperfusion. ( P 0.01). These results suggested that the increasing NO during hemorrhagic shock resuscitation might directly lead to vasodilation to decrease blood vessel resistance and blood pressure. Taurine has a beneficial effect in maintaining the blood pressure, mechanism of which may be related to decreasing the generation of NO.