Clinicopathological features and prognosis of 1829 patients with primary colorectal cancer

Objective To evaluate the relationship between the clinicopathologic features and prognosis of colorectal cancer. Methods From January 1991 to December 2002,clinical data of 1829 patients who had been histologically proven to suffer from colorectal adenocarcinoma were statistically analyzed using a model of Cox with SPSS 10.0 software,the effect of independent factor on prognosis was determined. Results The mean survival time of 1829 colorectal cancer patients was 76.8 months and the overall 5 year survival rate was 56.9%. Univarite analysis showed that the predictors of survival in colorectal cancer patients were age,the onset time,tumor location,operative types (radical resection or non radical resection),histological type,diameter of the tumors,depth of tumor invasion,lymphatic invasion,distant metastases and Dukes staging. Multivariate analysis showed that only tumor location,radical resection,histological type,diameter of the tumors,depth of tumor invasion,lymphatic invasion and Dukesstaging were independent factors. Conclusion Early diagnosis and early treatment of colorectal cancer can achieve maximal improvement of survival rate and the quality of life.