Observation on the Clinical Efficacy of Early Therapeutic with High Dose Ulinastatin in the Treatment of Acute Pulmonary Contusion

Objective: To investigate the clinical efficacy of early therapeutic with high dose ulinastatin in the treatment of acute pulmonary contusion. Methods: A total of 102 patients with pulmonary contusion were randomly divided into Group A(n=34, control group), Group B(n=34, regular dose group) and Group C(n=34, high dose group). The patients of Group A received routine treatment,while the patients of Group B were given Ulinastatin(100 kU intravenous drip once every 8 hours and continued 7 days) in addition, and the patients of Group C also were given Ulinastatin(400 kU intravenous drip once every 8 hours and continued 7 days) in addition.Artery oxygen pressure(PaO2), carbon dioxide pressure(PaCO2), oxygenation index(PaO2/FiO2), serum tumor necrnsis factor alpha(TNF-α) and interleukin 6(IL-6) levels were measured on the 1st, 4th and 7th day in these groups. The incidence rates of acute respiratory distress syndrome(ARDS) and pulmonary infection were compared among three groups during the treatment. Results: After treatment,PaO2 in group B was higher than that in group A on 7th day(P0.05), PaO2in group C was higher than that in group A on 1st, 4th and7th day(P0.05), PaO2in group C was higher than that in group B on 1st and 4th day(P0.05); PaCO2in group B and C were higher than that in group A on 4th day(P0.05); PaO2/FiO2in group B was higher than that in group A on 7th day(P0.05), PaO2/FiO2in group C were higher than those in group A and B on 4th and 7th day(P0.05); TNF-α in group B was lower than that in group A on 7th day(P0.05), TNF-α in group C was lower than that in group A on 4th and 7th day(P0.05), TNF-α in group C was also lower than that in group B on 4th day(P0.05); IL-6 in group B was lower than that in group A on 7th day(P0.05), IL-6 in group C was lower than those in group A and B on 4th and 7th day(P0.05). No significant difference was observed in the incidence rates of ARDS and pulmonary infection among three groups during the treatment. Conclusions: Early high-dose application of ulinastatin was obviously effective in the treatment of acute pulmonary contusion.