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The change of expression of NGF and its receptor in red nucleus of aged female rats

Yuanyuan Cui

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Abstract

Objective To observe the change of motor function and expression of NGF and its receptor in red nucleus of aged female rats.Methods Female Sprague Dawley(SD)rats were divided into two groups.There were aged group(twenty two-month-old)and young group(three-month-old).The motor function was evaluated by screen test,prehensile-traction test and balance beam test.Western blot technique was carried out to observe the expression of mature nerve growth factor(mNGF)and its high affinity receptor TrkA,Pro-NGF and its receptor p75NTR,coreceptor sortilin.Results Motor function of aged group was clearly inferior to that of young group.The strength of forelimb and sense of balance in aged group obviously declined.Western blot showed that compared with that of the young rats,the expression of mNGF and TrkA in red nucleus of aged rats was significantly decreased but the expression of Pro-NGF,p75NTR and sortilin was increased.Conclusion The decline of motor function and the expression of mNGF and TrkA in red nucleus are associated with aging of female rats.The change of NGF signaling pathway in red nucleus is related to the decline of motor function of aged female rats.

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Objective To observe the change of motor function and expression of NGF and its receptor in red nucleus of aged female rats.Methods Female Sprague Dawley(SD)rats were divided into two groups.There were aged group(twenty two-month-old)and young group(three-month-old).The motor function was evaluated by screen test,prehensile-traction test and balance beam test.Western blot technique was carried out to observe the expression of mature nerve growth factor(mNGF)and its high affinity receptor TrkA,Pro-NGF and its receptor p75NTR,coreceptor sortilin.Results Motor function of aged group was clearly inferior to that of young group.The strength of forelimb and sense of balance in aged group obviously declined.Western blot showed that compared with that of the young rats,the expression of mNGF and TrkA in red nucleus of aged rats was significantly decreased but the expression of Pro-NGF,p75NTR and sortilin was increased.Conclusion The decline of motor function and the expression of mNGF and TrkA in red nucleus are associated with aging of female rats.The change of NGF signaling pathway in red nucleus is related to the decline of motor function of aged female rats.

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Available abstract

Objective To observe the change of motor function and expression of NGF and its receptor in red nucleus of aged female rats.Methods Female Sprague Dawley(SD)rats were divided into two groups.There were aged group(twenty two-month-old)and young group(three-month-old).The motor function was evaluated by screen test,prehensile-traction test and balance beam test.Western blot technique was carried out to observe the expression of mature nerve growth factor(mNGF)and its high affinity receptor TrkA,Pro-NGF and its receptor p75NTR,coreceptor sortilin.Results Motor function of aged group was clearly inferior to that of young group.The strength of forelimb and sense of balance in aged group obviously declined.Western blot showed that compared with that of the young rats,the expression of mNGF and TrkA in red nucleus of aged rats was significantly decreased but the expression of Pro-NGF,p75NTR and sortilin was increased.Conclusion The decline of motor function and the expression of mNGF and TrkA in red nucleus are associated with aging of female rats.The change of NGF signaling pathway in red nucleus is related to the decline of motor function of aged female rats.

Key concepts: Nerve growth factor, Endocrinology, Internal medicine, Receptor, Red nucleus, Western blot, Tropomyosin receptor kinase A, Nucleus

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