Changes of bone mineral density in middle aged and elderly type 2 diabetic patients

Objective To investigate the changes of bone mineral density(BMD) in middle aged and elderly type 2 diabetic(T2DM) patients. Methods Dual energy X-ray absorptiometry was used to measure BMD at posteroanterior lumbar spine(L1-4) and left femoral neck(Neck),femoral trochanter(Troch),intertrochanter(Inter),total hip(Htot) and ward triangle(Ward) in 2 215 T2DM patients(1 142 males,1 073 females). Results ①BMD of L1-4,Neck,Troch,Inter,Htot and Ward decreased after 30 years old in T2DM patients.In all sites,BMD of Ward triangle had the lowest value and this is a sensitive area to predict low BMD.②BMD of the female was lower than that of the male at various sites(P0.01).The BMD of L1-4,Inter,Htot,Neck,Troch,Ward area in male vs female was respectively 0.88(0.10) vs 0.78(0.22),1.12(0.19) vs 1.00(0.23),0.96(0.16) vs 0.83(0.15),0.82(0.15) vs 0.73(0.18),0.69(0.14) vs 0.57,0.60(0.18) vs 0.52(0.22).③All subjects were divided in four groups according to body mass index(BMI) for comparison of BMD.BMD in all the sites showe increase trends with rising BMI. Conclusion Peak BMD was observed at the age range of 30-40 years at the various sites in patients with T2DM.Female has lower BMD than male at various sites in patients with T2DM.BMD at the various sites increased with rising BMI.