Expression and significance of P53 and CA153 in patients with breast carcinoma

Objective To investigate the expression of P53 and CA153 in patients with breast carcinoma, to seek their relationship with tumor differentiation, invasion and metastasis, and to study their clinic significance. Methods Immunohistochemistry(IHC) method and serum immunoradiometric assay(IRMA) was used to detect the expression of P53 and CA153 respectively, in 63 cases of breast carcinoma and 25 cases of benign breast disease. Results In 63 cases of breast carcinoma the positive rates of P53, CA153 were 33.3% and 49.2%, respectively, the concentration of serum CA153 was 38.3±29.3 U/ml, which were all significantly higher than that in benign control group( P 0.01); the positive expression of P53 was related to histopathologic grade, tumor size, clinical stage( P 0.05); the serum concentration and the positive rates of CA153 in breast carcinoma was related to histopathologic grade, tumor size and axillary lymph node metastasis( P 0.05), and the serum concentration of CA153 was also related to clinical stage( P 0.05); the positive expression of P53 was related to the serum concentration of CA153( P 0.05). Conclusion The expression of P53 and CA153 closely correlates with the carcinognesis, development, growth, differentiation or metastasis of breast carcinoma; detecting these indexes can be helpful in assessment of the malignancy grade and prognosis, or the early diagnosis and surveillance of breast carcinoma.