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Expression of HIF-2αand its relationship with proliferation and apoptosis in renal cell carcinoma

Kong Peng

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Abstract

Objective To study expression of hypoxia inducible factor-α(HIF-2α),microvessel density(MVD)and their relationship with proliferation and apoptosis in renal cell cancer(RCC). Methods Expression of HIF-2α,MVD,proliferation and apoptosis were assessed by DAKO Envision System and in situ nick end labelling methods.Results in 66 cases of renal clear cell cancer,the posi- tive rate of HIF-2αwas 68.2%.HIF-2αexpression increased as TNM stage increased(P＜0.01). HIF-2αwas positive correlative with MVD(r=0.786,P＜0.01).There was a inverse correlation be- tween HIF-2αlabeling index and apoptosis index(AI)(r=-0.560,P＜0.01)as well as MVD and AI (r=-0.618,P＜0.01).HIF-2αhad a negative correlation with AI/PI.Conclusion HIF-2αplays a critical role in glucose metabolism and angiogenesis with the development of RCC.Angiogenesis is cor- related with enhanced RCC progress by inhibiting apoptosis.

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Objective To study expression of hypoxia inducible factor-α(HIF-2α),microvessel density(MVD)and their relationship with proliferation and apoptosis in renal cell cancer(RCC). Methods Expression of HIF-2α,MVD,proliferation and apoptosis were assessed by DAKO Envision System and in situ nick end labelling methods.Results in 66 cases of renal clear cell cancer,the posi- tive rate of HIF-2αwas 68.2%.HIF-2αexpression increased as TNM stage increased(P＜0.01). HIF-2αwas positive correlative with MVD(r=0.786,P＜0.01).There was a inverse correlation be- tween HIF-2αlabeling index and apoptosis index(AI)(r=-0.560,P＜0.01)as well as MVD and AI (r=-0.618,P＜0.01).HIF-2αhad a negative correlation with AI/PI.Conclusion HIF-2αplays a critical role in glucose metabolism and angiogenesis with the development of RCC.Angiogenesis is cor- related with enhanced RCC progress by inhibiting apoptosis.

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Available abstract

Objective To study expression of hypoxia inducible factor-α(HIF-2α),microvessel density(MVD)and their relationship with proliferation and apoptosis in renal cell cancer(RCC). Methods Expression of HIF-2α,MVD,proliferation and apoptosis were assessed by DAKO Envision System and in situ nick end labelling methods.Results in 66 cases of renal clear cell cancer,the posi- tive rate of HIF-2αwas 68.2%.HIF-2αexpression increased as TNM stage increased(P＜0.01). HIF-2αwas positive correlative with MVD(r=0.786,P＜0.01).There was a inverse correlation be- tween HIF-2αlabeling index and apoptosis index(AI)(r=-0.560,P＜0.01)as well as MVD and AI (r=-0.618,P＜0.01).HIF-2αhad a negative correlation with AI/PI.Conclusion HIF-2αplays a critical role in glucose metabolism and angiogenesis with the development of RCC.Angiogenesis is cor- related with enhanced RCC progress by inhibiting apoptosis.

Key concepts: Angiogenesis, Apoptosis, Renal cell carcinoma, Proliferation index, Cell growth, Cancer research, Hypoxia (environmental), Stage (stratigraphy)

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