Clinical and pathological Analysis of 30 Cases with Small Cell Carcinoma of the Cervix

Objective To explore the feature in pathology,immunohistochemistry and biological behavior of small cell carcinoma of cervix(SCCC).Methods The clinical data of 30 cases with SCCC were reviewed,hematoxylin and eosin stained slice,immunohistological marker were used,clinical follow-up was performed and the related literature was reviewed.Results In these cases,the average age was 44 years old,irregular vagina bleeding was the most common clinical manifestations.Histologically,the neoplastic cells appeared small,round in solid sheets,scant cytoplasm,hyperchromatic nuclei and absence of nucleoli.Numerous mitotic figures and extensive necrosis were also common findings.The foci of squamous carcinoma or adenocarcinoma were identified in 8 cases.Immunohistochemical studies showed immunoreactivity for neuroendocrine markers,such as NSE,CHG-A and Syn.30 patients stained positive for at least two neuroendocrine markers.Treatments included surgery,radiation,chemotherapy or a combination of them.5 year survival rate was 29.4%.Conclusions SCCC is a rare and highly malignant tumor with distinct pathological features.Immunohistological staining may be helpful in diagnosis of SCCC.It is aggressive with early metastases and has a poor prognosis.