Concentration of VCAM-1 in Serum and Urine in Henoch-Schonlein Purpura Nephritis and its Clinical Significance

Objective:To explore the concentration of soluble vascular cellular adhesion molecule-1(sVCAM-1) in serum and urine in children with Henoch-Schonlein purpura nephritis(HSPN) and explore its clinical significance.Methods:There were 50 patients with HSP in the study.They were divided into two groups according to their renal lesions:30 cases with HSPN and 20 cases without HSPN(as NO-HSPN group).The control group included 20 healthy children.The concentration of sVCAM-1 in serum and urine of all children were detected by enzyme-linked immunosorbent assay(ELISA).Then we compared the concentrations in every group and analyzed the relationship between the concentrations of sVCAM-1 and the main clinical markers(including 24 hours urinary protein and urinary erythrocyte).Results:The serum concentrations of sVCAM-1 in HSPN group(809.79±173.32)ng/ml and NO-HSPN group(623.44±67.27)ng/ml were both significantly higher than those in the control group(494.79±59.84)ng/ml(P0.01).The serum concentration of sVCAM-1 in HSPN group was significantly higher than that in NO-HSPN group(P0.01).The urinary concentration of sVCAM-1 in HSPN group were significantly higher than those in NO-HSPN group(P0.01) and the control group(P0.01),but there was no significant difference between the NO-HSPN group and the control group(P0.05).The concentration of VCAM-1 in the proteinuria group was significantly higher than that in the no-proteinuria group(P0.01).The concentration of VCAM-1 in the nephropathy proteinuria group was significantly higher than those in the proteinuria group(P0.05) and the no-proteinuria group(P0.01).The serum concentration of sVCAM-1 in the gross hematuria group was significantly higher than that in the no-hematuria group(P0.01),but was not significantly different from that in the microscopic hematuria group(P0.05).The serum concentration of sVCAM-1 in the microscopic hematuria group was higher than that in the no-hematuria group(P0.01) too.The urinary concentrations of sVCAM-1 were different in the groups with different levels of hematuria,because sVCAM-1 levels were significantly higher in the gross hematuria group and the microscopic hematuria group than that in the no-hematuria group(P0.05).But it was not significantly different between the microscopic hematuria group and the gross hematuria group(P0.05).There was a significantly positive correlation between the concentration of sVCAM-1 both in serum and in urine and the level of 24 hours urinary protein and urinary erythrocyte too(P0.01).Conclusion:It suggest that VCAM-1 is involved in the course of the onset and the development of HSPN.The sVCAM-1 in urine is worthy of detection for monitoring the renal lesions.