Applicacation of acute hypervolemic hemodilution combined with hypotension controlled and autogolous (allogeneic) blood transfusion on patients undergoing total hip replacement

Objective To evaluate the clinic effects of acute hypervolemic hemodilution(AHH) combined with induced hypotension(CH) and autogolous(allogeneic) blood transfusion on patients undergoing total hip replacement.Methods Sixty patients undergoing total hip replacement randomly divided into two groups with 30 patients each.The patients in experimental group(n=30) receive 6% HES 15 ml/kg in 30 minutes after anesthesia,MAP were maintained in a range of(65±5) mm Hg by nitroglycerin.Control group(n=30)were managed in the same way,but induced artery blood pressure only in by nitroglycerin.The HR,MAP,CVP,blood loss,blood transfusion and the time of operation were recored.The Hb,Hct,PT,APTT and FG were measured at before of AHH,after of AHH and the end of operation.Results The blood loss in experimental group were significantly lower compared with its in control group(P0.01).The Hct and Hb in experimental group on after AHH and the end of operation were lower compared with those before AHH.The PT,APTT and FG were increased in experimental group as compared to that before AHH.No lung edema,heart failure and unconventionality bleeding occur in two groups.Conclusion AHH combined CH were safety and decrease blood loss in the total hip replacement,Autogolous blood transfusion can reduce the capacity of blood transfusion.