Comparative Research on the Blood IL-6、CK、CK-MM and Ca~(2+) Changes of Rats after Eccentric Exercise

Objective:To observe the changes of muscle structure and the blood IL-6,CK,CK-MM、Ca2+ after eccentric exercise.Methods: 40 SD rats were randomly divided into control group and exercise group.Exercise group were divided into subgroups of immediately after exercise,24h after exercise,48h after exercise,72h after exercise.Rats of exercise group were forced to have once treadmill(19-21m/min,-16°,90min) test.To observe the changes of soleus muscle and the blood IL-6,CK,CK-MM,Ca2+.Results:(1)The ultrastructure of muscle changed obviously after exercise.The changes were most serious at 24h-48h after exercise.(2)Plasm IL-6 increased significantly in instant,whereafter keep on decreasing,and increased significantly again in 72h.(3)Serum CK and CK-MM increased after exercise,decreased in 72h.(4)Serum Ca2+ level decreased significantly after exercise.Conclusion: Results indicated IL-6 could be an important index for determining skeletal muscle damage.The individual variation of CK and CK-MM is tremendous,so they fit the comparison of intrasubject.