Efficacy of Paroxetine combined with a small amount of Doxepin in the treatment of old age depression

Objective:To explore the clinical curative effects and safety of Paroxetine combined with a small amount of Doxepin in the treatment of old age depression.Methods:60 patients with of old age depression were randomly divided into study group(Paroxetine combined with a small amount of Doxepin group) and the control group(Paroxetine group) 30 cases each,Respectively,Taking Paroxetine combined with a small amount of Doxepin and Paroxetine treatment lasted 8 weeks.Clinical efficacies were assessed with the Hamilton anxiety scale(HAMA)、 the Hamilton Depression Scale(HAMD) and the Clinical Global Impression Severity of Illness(CGI-SI) and adverse reactions with the Treatment Emergent Symptom Scale(TESS) before treatment and after treatment.Results: The study group in the treatment of 2,4,6,8 weekend HAMA total score falls faster than the control group,the difference was statistically significant(P0.05),Study Group HAMA the less points rate higher than that of the control group were statistically significant differences(P0.05) in the treatment of the first 2,4 weekend.Study Group 8 weeks of treatment HAMD total score decreased significantly faster than the control group difference was statistically significant(P0.05).Study Group in the treatment of the first 2,8 weekend HAMD reduction rate higher than that of the control group difference was statistically significant(P0.05 or P0.01).The study group after 8 weeks of treatment the total effective rate was 80.00%,and 70.00% of the control group,the difference was not statistically significant(P0.05).The remarkable efficiency of the study group was 50.00% and 28.13% of the control group,the difference was statistically significant(P0.05).The adverse reaction rate was 50.00% higher than the 23.33%,but the difference was not statistically significant(P0.05).Conclusions: More effective than Paroxetine combined with a small amount of Doxepin in the treatment of senile depression with Paroxetine group and mild adverse reactions.