2002•Zhongguo linchuang jiepouxue zazhiRequires access

The study on gene expression changes of neuronal nitric oxide synthase in injured spinal cord tissue

Cheng Liu

Abstract

Objective: To study the gene expression changes of neuronal nitric oxide sythase (nNOS) in injured spinal cord tissue.Methods: A compression injured model of rat spinal cord was estabilished and gene expression level of nNOS was measured by revese transcription polymerase chain reaction (RT PCR) Results: Expression of nNOS mRNA was seen in non injured spinal cord tissue and was quickly upregulated after injury, reaching the maximum at 6 hours after injury. Conclusion: nNOS may play a negative role in the secondary spinal cord injury.

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Key concepts: Spinal cord, Spinal cord injury, Nitric oxide synthase, Nitric oxide, Gene expression, Reverse transcription polymerase chain reaction, Messenger RNA, Downregulation and upregulation