Significance of 299 cases Chromosomal analysis in prenatal diagnosis

[Objective] To study the relationship between fetal chromosomal abnormalities and prenatal diagnosis indication.[Methods] 299 cases Chromosomal results from amniotic fluid or cord blood cell cultured and stained by G- banding in Xiangya Hospital from 2001.1 to 2007.1 were investigated retrospectively, because of the indications to prenatal diagnosis on Down′s high-risk, adverse pregnancy history, parents chromosomal abnormalities and others. [Results] According to cases of the pregnant women participated in prenatal diagnosis, the top five were in turn Down′s high-risk (145 cases), adverse pregnancy history (65 cases), elder age (35 cases), fetal malformation (32 cases) and parents Chromosomal abnormalities (14 cases), respectively. Its percentage to the total cases were of 48.5%, 21.7%, 11.7%, 10.7% and 4.7%, respectively. By the number of fetal Chromosomal abnormalities detected, the top five were fetal malformation( 6 cases), Down's high-risk(4 cases ), elder age(3 cases),adverse reproductive history (3 cases), parents chromosomal abnormalities(1 cases), which accounted for total cases of 35.3%, 23.5%, 17.6%, 17.6% and 5.9%, respectively. By ratio of cases in pregnant women joined in prenatal diagnosis verse fetal Chromosomal abnormality, fetal malformation, the elderly, poor reproductive history, the parents of Chromosomal abnormalities, Down′s high-risk were ranked ,its rate were 18.75%, 8.57%, 4.62%, 2.76% and 1.97%. [Conclusion] ① The proportion of Chromosome abnormality detected in fetal malformation was rank to top in the indications of prenatal diagnosis. ②The number of Down′s high-risk pregnant women for prenatal diagnosis line is in the first position, but the rate of fetal chromosome abnormality detected was only abode in the fifth place.