Clinical Observation of Conscious Sedation in Elderly with Colonoscopy

Objective:To explore the safety of conscious sedation with target-controlled infusion of propofol and remifentanil for colonoscopy in elderly.Method: The plasma concentrations of target-controlled infusion of propofol was 0.5 ~ 1.5 μg/mL,the plasma concentrations of fentanyl was 0.5 μg/mL,80 cases were divided into conscious sedation group(n=40) and control group(n=40) in random.Bispectral index(BIS) in conscious sedation group 85±5,the BIS in control group maintain in 60±5.The preoperative,perioperative and postoperative mean arterial pressure(MAP),heart rate(HR),and pulse oxygen saturation(SpO2) were observed between two groups.The perioperative adverse reactions were recorded.Result: MAP,HR and SpO2 in every time point in conscious sedation group were no significantly different(P 0.05).HR and MAP at the time point of preanesthesia,the beginning of endoscopy and reaching ileocecum in control group were significantly different(P 0.05),and at the time point of preanesthesia and endoscopy finish were no significantly different(P 0.05).SpO2 in every time point in control group was no significantly different(P 0.05).the adverse reactions of arrhythmia,glossocoma,apnea in conscious sedation group decrease significantly(P 0.05).Conclusion: The way of conscious sedation with target-controlled infusion of propofol and remifentanil for colonoscopy in elderly is safer than traditional painless way.