The correlation between serum concentrations of apolipoprotein AV and level of Lipoprotein(a) in patients with coronary heart disease

Objective:To explore The correlation between serum concentrations of apolipoprotein AV and level of Lipoprotein(a) in patients with coronary heart disease(CHD).Method:The level of serum total cholesterol(TC),triglyceride(TG),high-density lipoprotein cholesterol(HDL-C),low density lipoprotein cholesterol(LDL-C),apolipoprotein A1(ApoA1),apolipoprotein B(ApoB) and Lipoprotein(a) were examined in 120 individuals by biochemistry department;enzyme-linked immunosorbent assay(ELISA) method was used to determine ApoAV.All individuals underwent coronary angiography were divided into two groups: 60 patients with CHD and 60 control individuals.Result:The concentrations of ApoAV,ApoAI and HDL-C in CHD groupswere significantly lower than the control groups [(206.76±135.95)μg/L vs(265.33±122.35)μg/L],[(1.09±0.26)g/L vs(1.23±0.25)g/L],[(1.22±0.29)mmol/L vs(1.31±0.21)mmol/L],P0.01;whereas TG and LP(a) levels were significantly higher than the control groups [(1.64±1.15)mmol/L vs(1.10±0.37)mmol/L],[(393.03±280.08)mg/L vs(218.37±60.58)mg/L],P0.01.Serum ApoAV was negatively correlated with TG and LP(a),but positively correlated with HDL-C.Conclusion:The patients with CHD have decreased serum levels of ApoAV and HDL-C,but increased levels of TG and LP(a).ApoAV and LP(a) have different influence in the development of CHD.