The clinical significance of vascular endothelial growth factor with acute cerebral infarction

Objective: To study the change of vascular endothelial growth factor(VEGF) in serum with acute cerebral infarction and the action of VEGF during the pathological process of acute cerebral infarction.Methods: Serum VEGF was determined by ELISA in 55 patients with acute cerebral infarction at 1,7,14 day and in 30 normal controls.Then to compare VEGF level with infarction volume,location and nerve function.Results: Level of VEGF in acute cerebral infarction patients was significantly increased at 1, 7,14 day than normal controls(P0.05).Further,Level of VEGF was significantly increased in a large infarct volume than that in less infarct volume(P0.05).Level of VEGF was significantly increased in serious nerve function scores than midrange and lower grade nerve function scores(P0.05).Level of VEGF was not difference with distinct location and nation.It was not statistically significance(P0.05).Conclusions: Level of VEGF in serum of acute cerebral infarction patients has a significant increase.It indicated VEGF may take part in the pathological process of acute cerebral infarction and reflect degree and prognosis of cerebral infarction.