2001•PubMedRequires access

[The characteristics of bcl-2 and PCNA expression in the lens epithelium of human being].

Jing-ning Weng, H Zhang

Abstract

OBJECTIVE: To investigate the characteristics of bcl-2 (gene inhibiting apoptosis) and proliferating cell nuclear antigen (PCNA) expression and their relation to the proliferation of lens epithelium. METHODS: The expression of bcl-2 and PCNA were detected by immunohistochemical streptavidin-peroxidase (SP) method. RESULTS: The expression of bcl-2 and PCNA in the lens epithelium of fetus and children was higher than that of the elderly, especially in the region of the lens equator. CONCLUSION: The over-expression of bcl-2 and PCNA in the lens epithelium of fetus and children suggests that bcl-2 and PCNA might be related to the development of cataract.

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Key concepts: Proliferating cell nuclear antigen, Epithelium, Immunohistochemistry, Biology, Lens (geology), Apoptosis, Cell biology, Immunology