2004•PubMedRequires access
[Clinical significance of expression of VEGF and bFGF in thyroid carcinoma].
Xiaofeng Tian, Xuewen Zhang, Rui-xin Chen, Jianwei Wang, Dan Zhang
Open publisher page 3 citations
Abstract
OBJECTIVE: To study the clinical significance of expression of VEGF and bFGF in thyroid carcinoma. METHODS: Immunohistochemical SP technic was used to investigate the expression of VEGF and bFGF in 90 cases of papillary carcinoma, 14 cases of undifferentiated carcinoma, 10 cases of normal thyroid tissue. RESULTS: The positive rate of VEGF and bFGF in thyroid carcinoma was 63.5% and 59.6% respectively, Which was significantly higher than that in normal thyroid tissue (P < 0.01); The positive rate of VEGF and bFGF in undifferentiated carcinoma was 92.9% and 85.7% respectively, which was significantly higher than that in papillary carcinoma (P < 0.05); The positive rate of expression of VEGF and bFGF was correlated with lymph gland metastasis (P < 0.05); A positive correlation between these two expresses existed in thyroid carcinoma (gamma = 0.596, P < 0.05). CONCLUSION: VEGF and bFGF can be regarded as a parameter to evaluate the biological behavior and prognosis of thyroid carcinoma.