Study on efficacy of Etanercept and Celecoxib in treatment of patients with ankylosing spondylitis

Objective To explore the efficacy and safety of Etanercept and Celecoxib in treatment of 36 patients with ankylosing spondylitis.Methods By the prospective study method,72 patients with ankylosing spondylitis were randomly divided into trial group and control group.Thirty six patients in trial group were given with Etanercept and Celecoxib for treatment,and 36 patients in control group were treated by Celecoxib and sulfasalazine.The clinical observation index and laboratory parameters were evaluated in both 2 groups after treatment for 16 weeks.Results The severity of lower back pain,degree of peripheral joint swelling and duration for morning stiffness were compared after treatment for 16 weeks,and their difference was statistically significant(P 0.05).Laboratory indexes including erythrocyte sedimentation rate,serum levels of C-reactive protein and TNF-α were compared,and their difference was statistically significant(P 0.05).The total rate of effectiveness(clinical ease plus marked improvement plus effectiveness) was 91.67%(33 /36) in trial group,and effective rate of control group was 72.22%(26 / 36).The total effective rate was compared between these 2 groups,and their difference was statistically significant(P 0.05).Conclusion The efficacy of Etanercept and Celecoxib in treatment of patients with ankylosing spondylitis is distinct,safe and compliance,hence it is the ideal choice for treatment of patients with ankylosing spondylitis.