The Effects of Propolis Capsule on Immunity Function of Mice

Objective To investigate the immune-regulating effect of the propolis capsule on mice.Methods 192 mice were randomly divided into four groups,and each group was divided into four groups(low dose group,medium dose group,high dose group and control group).In vivo normal mice,the tests were made that the ratio of spleen-thymus/body weight,T lymphocyte proliferation of mouse spleen induced by ConA,the response of delayed hypersensitivity,the level of serum hemolysin,antibody-producing cell assay,phagocytic activity of macrophages and the ability of macrophages for carbon particle clearance and cytotoxicity of NK cells by LDH method.Results The propolis capsule could increase the ability of macrophages for carbon clearance,the capacity of the response of delayed hypersensitivity induced by SRBC,the activity of natural killer cells,the level of serum hemolysin,the quantity of antibody-producing cells and the ability of T lymphocyte proliferation of mouse spleen induced by ConA in the high dose group;Compared with the control group,significant difference was found in the medium and high dose group in phagocytic activity of macrophages(Phagocytic rate and Phagocytic index,P0.05);Significant difference was not investigated in the ratio of spleen-thymus/body weight.Conclusion our results indicated that the propolis capsule could have enhancing effects on cell immunity,humoral immunity,the macrophage engulfing function and NK cell cytotoxicity in mice.So it has the function of enhancing immunity.