Methicillin-Resistant Staphylococcus Aureus to Vancomycin Values for 5 Years

Objective: To review and analyze the evolution of the MICs of vancomycin in methicillin-resistant Staphylococcus aureus(MRSA) strains isolated in our hospital during an five-year period to guide rational use of antimicrobial agents.Methods: The MICs of vancomycin were detected by broth macrodilution method on methicillin-resistant Staphylococcus aureus(MRSA) strains isolated from clinical specimens dring last 5 years,etermination of the results observed the standard of CLSI version 2010,and drug sensitivity analysis adopted WHONET5.5.Results: MRSA detection rate from 19.23 % in 2005 rose to 42.14 % in 2009,MICs geometri mean of vancomycin increased from 0.54 μg/ml to 1.21 μg/ml,No isolate was found drug resistanceto vancomycin and teicoplanin,Four strain of MRSA from 2007 to 2009 was intermediate to teicoplanin,The diameters(mm) of the inhibition zone were 12.0,12.0,13.0,12.0;The M ICs of vancomycin to 4 isolates were 4μg/ml.Conclusion: MRSA microorganisms are increasing from 2007 to 2009,MICs of vancomycin in MRSA indicated a trend of increasing;It is important to monitor the antimicrobial susceptibility of Staphylococcus aureus to vancomycin.